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Recently rolled this out, some brief notes: - On a Windows 10 machine, no additional agent is required. You simply set the SCCM policy to enable Endpoint Protection (Defender) to be managed. SCCM > Administration > Client Settings > Endpoint Protection > Manage Endpoint Protection...... - On a Windows 7 machine, SCCM will automatically deploy the SCEP agent if the above policy setting is enabled. We haven't deployed to server so cant assist there, but no reason why it wouldnt work. - You'll need to setup ADR's so new definitions are downloaded every X hour, you'll also need to change you SUP sync schedule to match this frequency - All settings/configuration/exclusions etc can be done via Anti-Malware policies. SCCM > Asset and Compliance > Endpoint Protection > Antimalware policies - I found we had to manually uninstall our previous AV solution (even though SCCM has an option to remove it) else SCEP would fail to install. I had to script the removal of the old AV Take some time to flick over all the anti-malware policies, everything will become much clearer. Key thing is to make sure your definitions are regularly updated (i do mine every 8 hours), and to make sure your SUP also sync at the same time else the ADR will run against a "outdated" SUP catalog.