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In the .HTA file I changed the following line: If DPI > 120 then DESIGN_DPI = 160 'dots per inch 'DESIGN_WIDTH = 450 'pixels 'DESIGN_HEIGHT = 365 'pixels DESIGN_WIDTH = dw 'pixels DESIGN_HEIGHT = dh 'pixels to If DPI > 120 then DESIGN_DPI = 96 'dots per inch <<--- 'DESIGN_WIDTH = 450 'pixels 'DESIGN_HEIGHT = 365 'pixels DESIGN_WIDTH = dw 'pixels DESIGN_HEIGHT = dh 'pixels This seems to have solved my scaling problems. You still need to adjust the Window size from above, reference: Call ReSizeWindow (425,335,500,535) in the code above the ReSizeWindow function. When the DPI is <120 the formula uses the design width and height 500,535 respectively. However when the DPI is >120 it will use the numbers 425,335 and then factor accordingly. To get mine to work I had to reduce those numbers somewhat but it now almost displaces the same as on a system with DPI set to 96.

@webguy that did the trick! Even at a ridiculous 175% scaling on 1920x1080, it's still fully readable and the buttons can be accessed.