yes, you need to do 3 things: 
  
1) 
ALTER DATABASE CM_<SiteCode>" SET TRUSTWORTHY ON  
  
2) 
ALTER DATABASE CM_<SiteCode> 
 SET ALLOW_SNAPSHOT_ISOLATION ON 
ALTER DATABASE CM_<SiteCode> 
 SET READ_COMMITTED_SNAPSHOT ON 
  
3) 
run against the configmgr database (CM_<SiteCode>) 
sp_changedbowner 'sa' 
  
h2h 
  
  
source: 
http://support.microsoft.com/kb/2709082