Thank you so much for your help.
I found some Event ID's that I think are going to tell us more.
The description for Event ID 9009 from source Microsoft-Windows-IIS-APPHOSTSVC cannot be found. Either the component that raises this event is not installed on your local computer or the installation is corrupted. You can install or repair the component on the local computer.
If the event originated on another computer, the display information had to be saved with the event.
and
On 4/20/2021 2:52:13 PM, component SMS_MP_CONTROL_MANAGER on computer \\server\.COM reported: MP Control Manager detected User Service is not responding to HTTP requests. The http error is 500.
Possible cause: IIS service is not responding.
Solution: Manually restart the W3SVC service.
and
Event ID 1284 An error occurred while trying to create the directory for the architecture.
Error Information: 0x3